Fresh skills to visualize axonal fiber bundles on the retina for early diagnosis of optic neuropathies

Fresh skills to visualize axonal fiber bundles on the retina for early diagnosis of optic neuropathies

A new technology to visualise axonal fibre bundles on the retina for early diagnosis of optic neuropathies
Credit: The College of Hong Kong

A compare crew led by the Division of Ophthalmology, College of Scientific Medicines, LKS Faculty of Medicines of The College of Hong Kong (HKUMed), with collaborators from the Faculty of Medicines of The Chinese College of Hong Kong (CU Medicines) and local and world companions, have developed a new skills ROTA (Retinal nerve fiber layer Optical Texture Diagnosis) to unveil the optical texture and trajectories of the axonal fiber bundles on the retina. ROTA outperforms the brand new clinical requirements, attaining 15.0% to 28.4% increased in sensitivity in detecting early optic nerve damage in glaucoma—the main motive within the back of irreversible blindness. The compare has been printed in Nature Biomedical Engineering.

Glaucoma is the most total originate of neurodegenerative illness. Whereas clinical diagnosis of glaucoma is predicated on the dimension of retinal nerve fiber layer (RNFL) thickness, in total purchased with a non-invasive digital imaging machine, optical coherence tomography (OCT), wrong positives and wrong negatives are total, which renders clinical interpretation of OCT findings advanced, even for glaucoma experts. Here’s supported by a meta-diagnosis reporting that the sensitivities of most productive-performing OCT parameters for detection of RNFL thickness abnormalities were most productive 65%–75% at specificities of 90%–95%.

ROTA is a patented algorithm that integrates RNFL thickness and RNFL reflectance measurements purchased from customary OCT scans to discern the optical texture and trajectories of the axonal fiber bundles and mark RNFL defects. ROTA can detect focal RNFL defects which shall be overlooked by customary clinical tests.

Compared with OCT, ROTA can develop the sensitivity of detecting early optic nerve damage in glaucoma by 15–22%. At 95% specificity, the sensitivity of ROTA was as soon as 97.3–98.4% for detection of early glaucoma, 15.0% to 28.4% increased than the brand new clinical requirements. HKUMed is working with the College of California San Diego (UCSD), the United States, to exercise ROTA in compare and affected person care, whereas sufferers can gain the applying of ROTA at HKU Peer Heart and Southern District Hong Kong Peer Compare.

In a diagnostic seek examining 177 wholesome folk and 363 glaucoma sufferers on the CUHK Peer Heart of CU Medicines, ROTA attained vastly increased sensitivity and specificity than extinct OCT RNFL thickness diagnosis to detect glaucoma. Furthermore, ROTA is able to establish axonal fiber bundle damage in optic neuritis, ischemic optic neuropathy, and compressive optic neuropathy.

“We are happy to have labored with CU Medicines to manufacture ROTA, which brings new hope to early identification and neatly timed remedy of glaucoma due to the its excessive sensitivity and specificity,” mentioned Professor Christopher Leung Kai-shun, Chairperson and Scientific Professor of the Division of Ophthalmology, College of Scientific Medicines, HKUMed. “Our next steps include enrolling sufferers from Queen Mary Scientific institution, Grantham Scientific institution, and Hong Kong Peer Scientific institution for longitudinal reports to survey the effectiveness of ROTA for detection of glaucoma development, as neatly as working with OCT industrial companions to deploy ROTA in clinical care. Furthermore, HKU Peer Heart welcomes sufferers with questionable diagnosis of glaucoma for ROTA review.”

Professor Clement Tham Chee-yung, Chairman of the Division of Ophthalmology and Visible Sciences and S.H. Ho Professor of Ophthalmology and Visible Sciences, CU Medicines, mentioned, “Glaucoma can lead to irreversible loss of vision, whether it’s a long way now not diagnosed and treated early. In Hong Kong, about 25% of irreversible blindness is attributable to glaucoma, and there are extra about 100,000 glaucoma sufferers tormented by varied ranges of visual disability. Attaining earlier diagnosis of glaucoma and detection of development thru evolved imaging technologies is needed. I’m delighted that ROTA was as soon as developed by CU Medicines and HKUMed’s collaboration and now it could well most likely well perchance even be extinct in clinical be conscious.”

ROTA underpins a highly sensitive and narrate technique to reach the diagnosis of glaucoma and optic neuropathies. ROTA will likely be deployed on the Developed Nerve and Glaucoma Imaging Community (ANGI Community), which contains ophthalmologists, neuro-ophthalmologists and clinical researchers round the arena.



Extra knowledge:
Christopher Kai Shun Leung et al, Diagnostic review of glaucoma and non-glaucomatous optic neuropathies via optical texture diagnosis of the retinal nerve fibre layer, Nature Biomedical Engineering (2022). DOI: 10.1038/s41551-021-00813-x

Quotation:
Fresh skills to visualize axonal fiber bundles on the retina for early diagnosis of optic neuropathies (2022, September 9)
retrieved 15 September 2022
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