Accessible bioengineered corneal tissue to take care of a blinding disease globally

Accessible bioengineered corneal tissue to take care of a blinding disease globally

Porcine dermal collagen become chemically and photochemically bioengineered into an implantable tissue mimicking the human corneal extracellular matrix. The implant gifts a extra effective and safer methodology than donor cornea transplantation while turning in identical outcomes, and has restored vision to of us with evolved keratoconus in handy resource-shrimp regions, where the burden of blindness is highest.

Your institute doesn’t maintain rating admission to to this text

Get entry to alternate ideas

Subscribe to Nature+

Get quick online rating admission to to the overall Nature family of 50+ journals

Subscribe to Journal

Get chubby journal rating admission to for 1 year


simplest $8.25 per affirm

All costs are NET costs.

VAT will probably be added later within the checkout.

Tax calculation will probably be finalised all the procedure thru checkout.

Exhaust article

Get time shrimp or chubby article rating admission to on ReadCube.


All costs are NET costs.

Fig. 1: From laboratory to vision restoration.


  1. Jeng, B. H. & Ahmad, S. In pursuit of the elimination of corneal blindness: is organising glimpse banks and training surgeons enough? Ophthalmology 128, 813–815 (2021). An Editorial highlighting the pain of world rating admission to to corneal transplantation.


    Google Student 

  2. Mathews, P. M., Lindsley, K., Aldave, A. J. & Akpek, E. K. Etiology of world corneal blindness and current practices of corneal transplantation: a centered overview. Cornea 37, 1198–1203 (2018). A Review highlighting keratoconus as the important thing indication for corneal transplantation in a total lot of the arena, emphasizing the need for much less invasive surgical contrivance and improved rating admission to to donor tissue.


    Google Student 

  3. Manufacture, P. et al. Global see of corneal transplantation and glimpse banking. JAMA Ophthalmol. 134, 167–73 (2016). A world see reporting regional disparities within the provision of donor corneal tissue.


    Google Student 

  4. Zirm, E. K. Eine erfolgreiche totale Keratoplastik [A successful total keratoplasty]. Refract. Corneal Surg. 5, 258–261 (1989). Reprint in English of Zirm’s long-established 1906 paper describing the first a success human corneal transplant.


    Google Student 

  5. Spinozzi, D. et al. In vitro overview and transplantation of human corneal endothelial cells cultured on biocompatible carriers. Cell Transplant. 29, 963689720923577 (2020). A piece of writing describing corneal endothelial cells cultured on a bioengineered collagen membrane a lot like the one in this see.


    Google Student 

Download references

Additional records

Publisher’s point out Springer Nature stays unbiased in regards to jurisdictional claims in published maps and institutional affiliations.

Right here is a summary of: Rafat, M. et al. Bioengineered corneal tissue for minimally invasive vision restoration in evolved keratoconus in two scientific cohorts. Nat. Biotechnol. (2022).

About this text

Verify currency and authenticity via CrossMark

Cite this text

Accessible bioengineered corneal tissue to take care of a blinding disease globally.
Nat Biotechnol (2022).

Download citation

  • Published:

  • DOI: