Porcine dermal collagen become chemically and photochemically bioengineered into an implantable tissue mimicking the human corneal extracellular matrix. The implant gifts a extra effective and safer methodology than donor cornea transplantation while turning in identical outcomes, and has restored vision to of us with evolved keratoconus in handy resource-shrimp regions, where the burden of blindness is highest.
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Jeng, B. H. & Ahmad, S. In pursuit of the elimination of corneal blindness: is organising glimpse banks and training surgeons enough? Ophthalmology128, 813–815 (2021). An Editorial highlighting the pain of world rating admission to to corneal transplantation.
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Zirm, E. K. Eine erfolgreiche totale Keratoplastik [A successful total keratoplasty]. Refract. Corneal Surg.5, 258–261 (1989). Reprint in English of Zirm’s long-established 1906 paper describing the first a success human corneal transplant.
Spinozzi, D. et al. In vitro overview and transplantation of human corneal endothelial cells cultured on biocompatible carriers. Cell Transplant.29, 963689720923577 (2020). A piece of writing describing corneal endothelial cells cultured on a bioengineered collagen membrane a lot like the one in this see.
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Right here is a summary of: Rafat, M. et al. Bioengineered corneal tissue for minimally invasive vision restoration in evolved keratoconus in two scientific cohorts. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01408-w (2022).
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Accessible bioengineered corneal tissue to take care of a blinding disease globally. Nat Biotechnol (2022). https://doi.org/10.1038/s41587-022-01409-9